William Sargent’s updated second edition of Crab Wars, released first in 2003 and again in 2021, serves as a twenty-year retrospective on the state of the horseshoe crab, a timely argument for protecting the species, and a cautionary tale. Certainly, the current pandemic, certain prospect of more in the future, and the tsunami of biotechnological developments in recent years, many driven by the pandemic, make the horseshoe crab’s survival more important than ever.